Hypoxia-induced RCOR2 promotes macrophage M2 polarization and CD8 <sup>+</sup> T-cell exhaustion by enhancing LIF transcription in hepatocellular carcinoma
Our research reveals that the RCOR2/LIF axis within the hypoxic microenvironment of HCC plays a significant role in immune evasion and identifies novel biomarkers associated with tumor resistance to anti-PD-1 therapy. This study provides potential therapeutic targets for HCC.
Authors
- Wenzhou Ding (ORCID: https://orcid.org/0009-0003-3734-7112)
- Qingpeng Lv
- Wenbo Jia (ORCID: https://orcid.org/0000-0002-7782-8127)
- Zhijie Ding (ORCID: https://orcid.org/0000-0002-4290-4513)
- Wenhu Zhao
- Xiaoming Ai (ORCID: https://orcid.org/0000-0002-5727-6644)
- Yong Yan (ORCID: https://orcid.org/0000-0002-8192-2378)
- Chao Xu (ORCID: https://orcid.org/0000-0002-9829-6887)
- Xiangyu Ling
- Weiming Yang
- Jinyi Wang (ORCID: https://orcid.org/0000-0001-5839-0388)
- Yongping Zhou (ORCID: https://orcid.org/0000-0003-1685-0491)
- Zhu Deming
- Yanzhi Feng
- Litao Liang
- Lianbao Kong (ORCID: https://orcid.org/0000-0001-7209-0365)
Institutions
- Jiangsu University (CN)
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Wuxi No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
- Academia Sinica (TW)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012314
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University
- Wuxi Municipal Bureau on Science and Technology