Anticoronavirus Isoquinoline Alkaloids: Unraveling the Secrets of Their Structure–Activity Relationship
This study highlights the antiviral potential of bis-benzylisoquinoline and Amaryllidaceae alkaloids, particularly aromoline. The findings support their relevance as scaffolds for developing novel anticoronavirus agents and advance the understanding of their structure-activity relationships.
Authors
- Marcela Šafratová (ORCID: https://orcid.org/0000-0003-4690-5107)
- Jakub Chlebek (ORCID: https://orcid.org/0000-0002-0697-5242)
- Tsong‐Long Hwang (ORCID: https://orcid.org/0000-0002-5780-3977)
- Anders Backlund (ORCID: https://orcid.org/0000-0003-2043-4183)
- Lucie Cahlíková (ORCID: https://orcid.org/0000-0002-1555-8870)
- Anna Hošťálková (ORCID: https://orcid.org/0000-0003-3205-3767)
- Jim‐Tong Horng (ORCID: https://orcid.org/0000-0001-6294-9981)
- Michal Kořínek (ORCID: https://orcid.org/0000-0002-8988-8610)
- Štefan Kosturko (ORCID: https://orcid.org/0009-0008-3596-5159)
- Yu‐Li Chen (ORCID: https://orcid.org/0000-0002-9742-4752)
- Bing‐Hung Chen (ORCID: https://orcid.org/0000-0001-5960-5176)
- Chung‐Fan Hsieh
Institutions
- Uppsala University (SE)
- Chang Gung University of Science and Technology (TW)
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- Charles University (CZ)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Influenza and Other Respiratory Viruses
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1111/irv.70166
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Karlova v Praze
- National Sun Yat-sen University
- University of Portsmouth
- European Commission
- Chang Gung University
- Chang Gung Medical Foundation
- Kaohsiung Medical University
- National Science and Technology Council