A Literature Review on Antioxidant Potential of Yellow Pumpkin Seed Extract in Skin Photoaging

Skin is the outermost part of the body that functions as protection. Skin aging is a complex biological process occuring in skin layer which causes changes in skin appearance and is divided into 2 categories, intrinsic (chronological) and extrinsic. Extrinsic aging is caused by external factors such as exposure to ultraviolet (ultraviolet (UV)) rays, pollutants and smoking. ultraviolet (UV) exposure can create reactive oxygen species (ROS) and causes cell damage and oxidative stress. It can be overcome by administering antioxidants. Pumpkin seed extract which can be found widely, contains linoleic acid, zinc, -carotene and tocopherol. It can protect cells from free radical oxidation with lipids produced in the lipid peroxidation chain reaction by providing electrons to free radical molecules. This article presents a literature review of the Antioxidant Potential of Yellow Pumpkin Seed of 10-year period. We identified 6 studies regarding pumpkin seed extract effect toward skin photoaging from in vivo or in vitro studies from 10 years period (From January 2015 to January 2025). Several protective mechanism of pumpkin seed extract were described, such as its flavonoid content against ultraviolet (UV), its 22% sun protection factor (SPF) content against ultraviolet (UV)B and its moisturizing effect from its high fatty acids content that help to repair skin barrier and maintaining moisture along with its ability to increase collagen density and to accelerate wound healing.