Analisis korelasi volume rata-rata platelet (Mean Platelet Volume) dengan mortalitas pasien sepsis

Background: Mean Platelet Volume (MPV) is a routine hematological parameter that reflects the average size of platelets. Elevated MPV levels have been associated with inflammatory conditions, including sepsis. MPV is also linked to stroke, cardiovascular risk, and metabolic disorders. However, the relationship between MPV and mortality in septic patients remains unclear. This study aimed to evaluate the correlation between mean platelet voMPV) levels and mortality in patients with sepsis. Methods: A prospective cohort study was conducted at Dr. Saiful Anwar General Hospital from March to November 2018. The diagnosis of sepsis was established based on The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). MPV was measured using flow cytometry within the first two days of hospital admission. Mortality data were obtained from medical records. Statistical analysis was performed using SPSS version 24, with a significance level set at ⍺<0.05. Results: A total of 68 sepsis patients were included, with 61.76% mortality and 38.24% showing clinical improvement. There was no significant difference in age between survivors and non-survivors (p=0.076). MPV levels were significantly higher in patients who died compared to those who improved (p=0.007). A significant positive correlation was found between MPV and mortality (r=0.329; p=0.006). Conclusion: MPV was significantly correlated with mortality in septic patients. Those with MPV >11 had a 1.6 times higher risk of death compared to patients with lower MPV values. Latar Belakang: Mean Platelet Volume (MPV) merupakan parameter hematologi rutin yang mencerminkan ukuran rata-rata trombosit. Peningkatan MPV sering dikaitkan dengan proses inflamasi, termasuk pada kondisi sepsis. Selain itu, MPV juga berhubungan dengan berbagai penyakit seperti stroke, gangguan kardiovaskular, dan penyakit metabolik. Namun, hubungan antara MPV dan mortalitas pada pasien sepsis masih belum sepenuhnya dipahami. Penelitian ini bertujuan untuk mengevaluasi korelasi antara kadar MPV dengan angka kematian pada pasien sepsis. Metode: Penelitian kohort prospektif ini dilaksanakan di RSU dr. Saiful Anwar antara Maret hingga November 2018. Diagnosis sepsis ditegakkan berdasarkan kriteria Sepsis-3. Data MPV diukur menggunakan metode flow cytometry dalam dua hari pertama perawatan, dan data mortalitas diperoleh dari rekam medis pasien. Analisis statistik dilakukan dengan SPSS v.24 menggunakan tingkat signifikansi ⍺<0,05. Hasil: Sebanyak 68 pasien sepsis dianalisis, dengan angka kematian 61,76% dan 38,24% mengalami perbaikan. Tidak terdapat perbedaan usia yang signifikan antara kelompok yang meninggal dan yang selamat (p=0,076). Nilai MPV secara signifikan lebih tinggi pada pasien yang meninggal (p=0,007). Terdapat korelasi positif antara MPV dan mortalitas (r=0,329; p=0,006). Simpulan: MPV menunjukkan korelasi signifikan dengan mortalitas pada pasien sepsis. Pasien dengan MPV >11 memiliki risiko kematian 1,6 kali lebih tinggi dibandingkan dengan pasien dengan MPV lebih rendah.