Magnesium Alterations in Human Spaceflight

Microgravity may be associated with early renal magnesium losses and a progressive increase in serum magnesium. This could be a result of initial fluid shifts and neurohormonal changes, followed by progressive loss from bone and muscle, potentially exacerbated by insufficient dietary intake. Data are limited to missions less than 6 mo, leaving long duration consequences unknown. Further research is needed to confirm trends and explore underlying mechanisms. Diaz TE, Sullivan RD, Ashworth ET, Buesking SC, Haggarty AM, Carmichael BDM, Singh G. Magnesium alterations in human spaceflight. Aerosp Med Hum Perform. 2025; 96(10):919-930.