Tooth Loss-Induced Gut Dysbiosis Promotes Neuroinflammation via L-Asparagine-Mediated Neuronal Toxicity
This study demonstrated that molar extraction in mice disrupted gut microbiota and promoted neuroinflammation via L-Asparagine, suggesting that maintaining oral integrity might help preserve neurological health. This could open new avenues for microbiota-targeted interventions in neurodegenerative disease prevention.
Authors
- Na Guo (ORCID: https://orcid.org/0000-0001-5250-7047)
- Qingsong Jiang (ORCID: https://orcid.org/0000-0003-2553-1863)
- Wei Wei (ORCID: https://orcid.org/0000-0001-5874-3825)
- Sirui Liu (ORCID: https://orcid.org/0000-0001-8476-4558)
- Z. Ryan Tian (ORCID: https://orcid.org/0000-0002-5644-8483)
- Zhaoxin Ji
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1016/j.identj.2025.103929
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16