Efficient syntheses of 2-amino-4 <i>H</i> -pyrans <i>via</i> gold-catalyzed cyclization of diester-tethered ynamides
Gold-catalyzed intramolecular cyclizations of diester-tethered ynamides are reported herein. This protocol exhibited a high functional group tolerance and broad substrate scope. A variety of functionalized 2-amino-4<i>H</i>-pyrans were obtained in up to 95% yield with 0.5-5 mol% catalyst loading. The reaction could be scaled-up and downstream transformations were also performed.
Authors
- Jianfeng Zheng (ORCID: https://orcid.org/0000-0002-3330-548X)
- Jiaxin Yang (ORCID: https://orcid.org/0000-0003-3725-5317)
- Yunfei Cai (ORCID: https://orcid.org/0000-0003-4823-8221)
- Yuhan Ye (ORCID: https://orcid.org/0009-0004-5292-7104)
- Dong Xiong (ORCID: https://orcid.org/0000-0003-2759-7663)
- Zeyu Yang (ORCID: https://orcid.org/0009-0006-5622-8604)
- Luhao Tang
Institutions
- Chongqing University (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04409j
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00