The Multifaceted Roles of PP2A-B56 in Tumor Progression

Protein phosphatase 2A (PP2A) regulatory B56 subunits play multifaceted and context- dependent roles in cancer progression by modulating key signaling pathways that govern cell growth, survival, migration, and apoptosis. Dysregulation of PP2A-B56 complexes is commonly observed across diverse malignancies, contributing to oncogenic signaling, therapy resistance, and tumor development. Recent advances have uncovered complex mechanisms controlling PP2A-B56 function, including post-translational modifications such as nitration and phosphorylation, protein interactions, and viral exploitation, highlighting the nuanced role of these subunits in tumor biology. The development of isoform-specific modulators and innovative biosensors offers promising avenues for precise therapeutic targeting of PP2A-B56 dysfunction in cancer. Continued investigation into the regulatory networks and context-specific functions of PP2A-B56 is critical for unlocking new strategies to combat tumor progression and overcome treatment resistance.