A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)
The CRHTRA1 rat recapitulates many pathological changes that are consistent with both clinical CARASIL pathology and studies of HTRA1 function <i>in vitro</i>.
Authors
- Xiaoyue Zhu (ORCID: https://orcid.org/0000-0003-2704-4938)
- William E. Van Nostrand
- Brittany Monte (ORCID: https://orcid.org/0000-0002-3060-5145)
- Marta Cabral (ORCID: https://orcid.org/0000-0002-4123-5848)
- Helene Benveniste (ORCID: https://orcid.org/0000-0002-2887-6667)
- John K. Robinson
- Sunil Koundal (ORCID: https://orcid.org/0000-0003-3969-1091)
- Mark J. Majchrzak (ORCID: https://orcid.org/0000-0002-9036-2608)
- Feng Xu (ORCID: https://orcid.org/0009-0003-2371-9579)
- Judianne Davis
- Hedok Lee
- Waela M. Van Nostrand
- Bethany Healey
Institutions
- University of Rhode Island (US)
- Yale University (US)
Publication Details
- Journal
- Cerebral Circulation - Cognition and Behavior
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.cccb.2025.100401
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00