Rethinking the effects of working memory training on executive functions in schizophrenia: A machine learning approach

Working memory training induces meaningful shifts in EF profiles in schizophrenia, promoting movement along the psychosis-health continuum toward neurotypical functioning. The classifier-based approach provides a more refined assessment compared to traditional binary measures, while the exploratory framework identifies specific EF domains predicting treatment response with potential causal relevance. These findings warrant validation through larger, multi-center trials with extended follow-up periods.