Candida

Invasive candidiasis is a serious and life-threatening disease in thoracic organ transplant recipients. <i>Candida</i> can transition from colonizer to opportunistic pathogen quickly in these hosts. This review explores the epidemiology, clinical presentation, diagnosis and management of invasive candidiasis in thoracic organ transplant recipients. We focus on the various manifestations of invasive candidiasis, including candidemia, endobronchial and anastomotic infections, pleural space infections, mediastinitis, and sternal osteomyelitis. We also discuss current therapeutic approaches, the challenges in managing these infections, and the emerging threat of resistant <i>Candida</i> species in this patient population.

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Publication Details

Journal
JHLT Open
Published
2025-10-04
DOI
https://doi.org/10.1016/j.jhlto.2025.100401
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Candida

Stephanie M. Pouch, Emily M. Eichenberger
JHLT Open
Antifungal resistance and susceptibility
article

Candida

Stephanie M. Pouch, Emily M. Eichenberger
article en

Abstract

Invasive candidiasis is a serious and life-threatening disease in thoracic organ transplant recipients. <i>Candida</i> can transition from colonizer to opportunistic pathogen quickly in these hosts. This review explores the epidemiology, clinical presentation, diagnosis and management of invasive candidiasis in thoracic organ transplant recipients. We focus on the various manifestations of invasive candidiasis, including candidemia, endobronchial and anastomotic infections, pleural space infections, mediastinitis, and sternal osteomyelitis. We also discuss current therapeutic approaches, the challenges in managing these infections, and the emerging threat of resistant <i>Candida</i> species in this patient population.

JHLT OpenVol. 10
Emory University (US)
Openalex Percentile: Top 67%
Antifungal resistance and susceptibility
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