Metagenomics next-generation sequencing for diagnosis of invasive fungal diseases in patients with hematological diseases
mNGS has high sensitivity in detecting IFD in patients with hematological diseases. Cluster of differentiation 4+ cell count below 400/uL, increased level of C-reactive protein, IL-6, and IL-10, hypoproteinemia, and neutropenia lasting for more than 10 days are independent risk factors for IFD in patients with hematological diseases.
Authors
- Yun Lian (ORCID: https://orcid.org/0000-0001-7993-2190)
- Hongchao Qin (ORCID: https://orcid.org/0000-0003-4364-0633)
- Qiqiang Long
- Xi Chen (ORCID: https://orcid.org/0000-0002-5166-0872)
- Yuhua Song
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Nantong Maternity and Child Health Hospital (CN)
Publication Details
- Journal
- IJID Regions
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.ijregi.2025.100780
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00