A Case of Rapidly Progressive Subglottic Hemangioma in an Infant: Early Propranolol Therapy Prevented Tracheostomy

Subglottic hemangioma is a rare but potentially life-threatening cause of neonatal airway obstruction. We report the case of a preterm infant who developed rapidly progressive biphasic stridor at 36 days of life. Flexible laryngoscopy revealed a subglottic mass, and contrast-enhanced computed tomography demonstrated a well-circumscribed, enhancing lesion causing >70% airway narrowing. Following careful airway planning, the patient was intubated safely and treated with oral propranolol, resulting in marked regression within 10 days and successful extubation without tracheostomy. The infant remained symptom-free, with no recurrence at 24 months. This case highlights the importance of early recognition of biphasic stridor, prompt laryngoscopic evaluation, and timely propranolol initiation, which may avert invasive surgical interventions.

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Publication Details

Journal
Cureus
Published
2025-10-03
DOI
https://doi.org/10.7759/cureus.93798
Primary Topic
Vascular Malformations and Hemangiomas
Type
article
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article

A Case of Rapidly Progressive Subglottic Hemangioma in an Infant: Early Propranolol Therapy Prevented Tracheostomy

Ko Matsui, Arata Horii, Takeshi Takahashi, Genki Iwai et al.
Cureus
Vascular Malformations and Hemangiomas
article

A Case of Rapidly Progressive Subglottic Hemangioma in an Infant: Early Propranolol Therapy Prevented Tracheostomy

Ko Matsui, Arata Horii, Takeshi Takahashi, Genki Iwai, Hironori Baba
article en

Abstract

Subglottic hemangioma is a rare but potentially life-threatening cause of neonatal airway obstruction. We report the case of a preterm infant who developed rapidly progressive biphasic stridor at 36 days of life. Flexible laryngoscopy revealed a subglottic mass, and contrast-enhanced computed tomography demonstrated a well-circumscribed, enhancing lesion causing >70% airway narrowing. Following careful airway planning, the patient was intubated safely and treated with oral propranolol, resulting in marked regression within 10 days and successful extubation without tracheostomy. The infant remained symptom-free, with no recurrence at 24 months. This case highlights the importance of early recognition of biphasic stridor, prompt laryngoscopic evaluation, and timely propranolol initiation, which may avert invasive surgical interventions.

CureusVol. 17(10)
University of Niigata Prefecture (JP), Niigata University of Rehabilitation (JP), Niigata University Medical and Dental Hospital (JP), Niigata University (JP)
Openalex Percentile: Top 56%
Vascular Malformations and Hemangiomas
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