Bacterial cellulose as a sustainable vehicle for the controlled release of nisin and mandelic acid: A clean beauty-based approach for acne treatment

Acne is a highly common skin condition, estimated to affect 94% of the global population at some point in their lives. Today, there is a growing demand for environmentally conscious products that treat skin diseases without harming the environment, known as Clean Beauty. For this reason, the objective is to develop a delivery system based on bacterial cellulose loaded with natural actives nisin and mandelic acid for acne treatment. The system, using bacterial cellulose (BC) from Komagataebacter xylinus fermentation, was tested for antibacterial and antioxidant activity, active release, cytotoxicity, Scanning Electron Microscopy, and product stability. The results of this study are promising: the BC system exhibited potent antibacterial activity against both standard and skin-isolated strains, along with high antioxidant activity. The controlled release of active ingredients, peaking at 300 minutes, and the stability of antibacterial and antioxidant properties over 180 days, underscore the system's potential as a shelf-stable product. Additionally, the minimal cytotoxicity observed affirms the safety of the formulation. This innovative approach not only aligns with the principles of Clean Beauty by avoiding petroleum-based components but also provides a sustainable and effective solution for managing acne. The integration of natural actives within a biodegradable matrix positions this product as a frontrunner in the future of dermocosmetics, meeting consumer demands for products that are both skin-friendly and environmentally responsible. • Development of a bacterial cellulose delivery system for acne treatment • Incorporation of natural actives nisin and mandelic acid with antibacterial action • Demonstrated antioxidant and controlled release properties • Low cytotoxicity and high biocompatibility confirmed in fibroblast cell line • Eco-friendly formulation aligned with Clean Beauty principles