Schaftoside ameliorates MCD diet-induced nonalcoholic steatohepatitis via modulating immune microenvironment
In summary, our study provides the first evidence that SS exerts anti-NASH effects by orchestrating immune cell functions, particularly through macrophage polarization and dendritic cell modulation, thereby rectifying the dysregulated immune microenvironment. These findings position SS as a promising candidate for novel NASH therapies.
Authors
- Tingting Duan (ORCID: https://orcid.org/0000-0003-2140-9967)
- Minyi Li (ORCID: https://orcid.org/0000-0002-5372-0365)
- Ziyang Lin (ORCID: https://orcid.org/0000-0001-7228-6851)
- Meng‐Qiu Li
- Dan Tang (ORCID: https://orcid.org/0000-0003-0364-2220)
- Bing Liang (ORCID: https://orcid.org/0000-0001-9968-6177)
- Junzheng Yang (ORCID: https://orcid.org/0000-0001-9992-3179)
- Lanqing Meng
- Guixuan Lin
- Ying Du (ORCID: https://orcid.org/0000-0002-8273-3448)
- Tao Xia (ORCID: https://orcid.org/0009-0001-5343-2208)
- Minhua Li (ORCID: https://orcid.org/0009-0000-2077-110X)
- Ying Lai
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.phymed.2025.157365
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00