Therapeutic efficacy of external beam radiotherapy combined with anti-PD-L1 inhibition in a preclinical syngeneic head and neck cancer model
These results reveal spatial distribution of immune cells in the tumor microenvironment and underscore the role of EBRT regimens in modulating immune cell dynamics. This highlights the importance of optimising radiation protocols to inform combination therapy designs in preclinical models.
Authors
- Sophie Langdon (ORCID: https://orcid.org/0000-0002-8269-9606)
- Anthony Kong (ORCID: https://orcid.org/0000-0002-3989-3948)
- Samantha Y.A. Terry (ORCID: https://orcid.org/0000-0002-6497-6681)
- Kavitha Sunassee (ORCID: https://orcid.org/0000-0003-2726-333X)
- Arshiya Banu
- Adam Jones
- Tanzila Harun
- Adam Laouafa
Institutions
- King's College London (GB)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.ctro.2025.101054
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00