Comparison of HbA1c, Uric Acid/HDL-C ratio, and Electroneuromyography (ENMG) results in patients with Type 2 Diabetes Mellitus

This study aims to compare the uric acid/HDL-C ratio and electroneuromyography (ENMG) results in patients with type 2 diabetes mellitus (T2DM) and to investigate whether these parameters differ in the presence or absence of diabetic peripheral neuropathy (DPN). Additionally, it evaluates the potential of HbA1c and the uric acid/HDL-C ratio as biomarkers for diagnosing DPN. This study was carried out retrospectively in the Neurology Clinic of Gaziantep City Hospital. The participants included 50 T2DM patients diagnosed with DPN through ENMG, 50 Type 2 DM patients without DPN, and 50 healthy controls. Demographic data, biochemical parameters (uric acid, HDL cholesterol, HbA1c), and ENMG results were analyzed. Intergroup comparisons and correlation analyses were performed. No significant differences in the uric acid/HDL-C ratio were observed among T2DM patients with DPN, those without DPN, and healthy controls. Moreover, the correlation between the uric acid/HDL-C ratio and ENMG results was found to be limited. The present study does not support the use of the uric acid/HDL-C ratio for neuropathy diagnosis, indicating the need for further research.