Differential Effects of Exercise on the Lipid Profile of Normogycemic Offspring of T2DM Patients in Sagamu, South West Nigeria

Background: The primary causes of Type 2 Diabetes Mellitus (T2DM) are largely unknown but abnormal lipid Profile pattern has been reported to be a risk factor for the T2DM Objectives: This study was designed to assess the effect of exercise on lipid profile in offspring of T2DM parents compared with offspring of non-diabetic parents. Design: This study involved purposive selection of 100 offspring of T2DM parents attending Diabetic Clinic of Olabisi Onabanjo University Teaching Hospital, Sagamu and 100 offspring of non-diabetic parents who are undergraduate students aged between 25 and 50 years. Each participant followed a protocol of graded exercise using ‘‘tummy trimmer’’ everyday spending 30-45 minutes daily for 24weeks. Blood samples were obtained after an overnight fasting for determination of lipid profile using standard methods at baseline, six weeks, 12 weeks, 18 weeks and 24 weeks, respectively. Data were analysed using descriptive statistical analysis. Results: In ODP, the mean TC significantly reduced from 150.52mg/dl + 45.56 at baseline to 127.78mg/dl+38.50 after six months of exercise (p=0.001). The mean HDL significantly increased from 44.73mg/dl + 13.01 at baseline to 58.95mgdl+17.25 after six months of exercise(p=0.001). In OCP, the mean TC significantly reduced from 158.35mg/dl + 37.11 at baseline to 148.26mg/dl+34.77 after six months of exercise (p=0.001). The mean HDL significantly increased from 56.57mg/dl + 11.10 at baseline to 65.20mgdl+12.18 after six months of exercise(p=0.001). Conclusions: There is reduction in lipid profiles in all the participants who engaged in exercise. The reduction is more in the study group.