Syntheses of Pyrene-4,5-dione and Pyrene-4,5,9,10-tetraone
Improved gram scale synthesis procedures for the preparation of pyrene-4,5-dione and pyrene-4,5,9,10-tetraone are reported. Pyrene-4,5-dione has been synthesized using potassium persulfate as the oxidant and RuO<sub>2</sub>·<i>n</i>H<sub>2</sub>O as the catalyst in the biphasic CH<sub>2</sub>Cl<sub>2</sub>/H<sub>2</sub>O solvent mixture containing K<sub>2</sub>CO<sub>3</sub> as the base. We also developed several procedures for multigram scale oxidation of pyrene-4,5-dione to pyrene-4,5,9,10-tetraone, eliminating the need for chromatographic purification of the poorly soluble tetraone product.
Authors
- Aleksandrs Prokofjevs
- Tetyana Ignatova (ORCID: https://orcid.org/0000-0003-3859-6367)
- O. T. Balogun
- Besan Khader
Institutions
- Center for NanoScience (DE)
- North Carolina Agricultural and Technical State University (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1021/acs.joc.5c01542
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00