Rapid Mechanochemical Ring-Opening and 1,3-Bisfunctionalization of Donor–Acceptor Cyclopropanes: Regioselective C(sp<sup>2</sup>)–H Alkylation of Coumaran and Chromane
Regioselective alkylation of 2,3-dihydrobenzofuran (coumaran) and chromane was accomplished through the ring-opening of donor-acceptor cyclopropanes (DACs) under mechanochemical conditions. The developed mechanochemical protocol efficiently promotes the ring-opening of DACs. Importantly, it enabled the first mechanochemical 1,3-bisfunctionalization of DACs using a range of electrophiles, furnishing the target products in high yields and significantly reducing reaction times.
Authors
- Ferruh Lafzi (ORCID: https://orcid.org/0000-0002-3371-0899)
- Haydar Kilic (ORCID: https://orcid.org/0000-0002-7009-9953)
- Sumeyye Atis
Institutions
- Atatürk University (TR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1021/acs.joc.5c01198
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87