Discordance of Dual-Tracer PET/CT with Histopathology in a Grade I Pancreatic Neuroendocrine Tumor: A Diagnostic Conundrum
Abstract Neuro endocrine tumors (NETs) demonstrate complex biology where imaging and histology can at times show discordance in a real-world scenario. We herein present a patient of grade I pancreatic NET showing atypical low somatostatin receptor expression on 68Ga-DOTATATE PET/CT (positron emission tomography/computed tomography) but intense fluorine-18-deoxyglucose (18FDG) avidity, and when interpreted together, these findings showed discordance with histopathology. The case highlights the crucial role of dual-tracer PET/CT in navigating the tumor biology and landscape of NET and the need for novel strategies to complement traditional histopathology that would enable better therapeutic decision-making.
Authors
- Sandip Kanti Basu (ORCID: https://orcid.org/0000-0001-6607-2558)
- Keerti Sitani (ORCID: https://orcid.org/0000-0002-2374-8500)
- Gauri Deshpande (ORCID: https://orcid.org/0000-0002-9895-2995)
- Sneha Shah
Institutions
- Bhabha Atomic Research Centre (IN)
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- World Journal of Nuclear Medicine
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1055/s-0045-1812058
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00