Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction
This is the first evaluation of HER2/ERBB2 expression in GBC with PBM based on WES, HercepTest, and FISH. The significant increase in ERBB2 expression, driven by the synergistic interplay between GBC and PBM, underscores a critical molecular interaction that may inform the development of targeted therapeutic strategies.
Authors
- Daisuke Douchi (ORCID: https://orcid.org/0000-0003-4582-6589)
- Kei Nakagawa (ORCID: https://orcid.org/0000-0002-3058-5674)
- Toru Furukawa (ORCID: https://orcid.org/0000-0002-1083-2324)
- Taito Itoh (ORCID: https://orcid.org/0000-0002-2518-3865)
- Shunsuke Migita
- Shuichi Aoki (ORCID: https://orcid.org/0000-0003-4221-0236)
- Masamichi Mizuma (ORCID: https://orcid.org/0000-0002-6436-5477)
- Mitsuhiro Shimura (ORCID: https://orcid.org/0000-0002-4147-8081)
- Atsushi Masamune (ORCID: https://orcid.org/0000-0001-7184-7282)
- Takashi Kokumai
- A. Kusaka
- Shingo Yoshimachi (ORCID: https://orcid.org/0000-0002-8823-6696)
- Keigo Murakami (ORCID: https://orcid.org/0000-0001-7173-8553)
- Takayuki Miura (ORCID: https://orcid.org/0000-0003-1862-1254)
- Masahiro Iseki (ORCID: https://orcid.org/0000-0002-4954-3810)
- Hideo Ohtsuka (ORCID: https://orcid.org/0000-0001-5503-2163)
- Michiaki Unno (ORCID: https://orcid.org/0000-0002-2145-6416)
- Naoki Rikiyama
- Masaharu Ishida (ORCID: https://orcid.org/0000-0002-5047-287X)
- Hideaki Sato (ORCID: https://orcid.org/0000-0002-0794-5491)
- Shimpei Maeda (ORCID: https://orcid.org/0000-0001-9344-6527)
- S. Nakayama (ORCID: https://orcid.org/0000-0002-8727-0753)
- Shuichiro Hayashi
- Ming Zhu
Institutions
- Tohoku University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Tohoku Medical and Pharmaceutical University Hospital (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1007/s00535-025-02303-2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00