Alcohol consumption, genetic susceptibility, and risk of latent autoimmune diabetes in adults and type 2 diabetes: Findings from two population-based studies
Moderate alcohol intake was linked to reduced LADA risk, particularly in individuals with high T2D-PGS and low/intermediate-risk HLA genotypes, indicating that the association is primarily present for T2D-like LADA. The extent to which genetic predisposition influences the association between alcohol and T2D remains less clear.
Authors
- Josefin E. Löfvenborg
- Emma Ahlqvist (ORCID: https://orcid.org/0000-0002-6513-2384)
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Anna‐Maria Lampousi (ORCID: https://orcid.org/0000-0002-3640-3827)
- Daniela Di Giuseppe (ORCID: https://orcid.org/0000-0003-3817-8288)
- Sofia Carlsson (ORCID: https://orcid.org/0000-0002-9497-2331)
- Bjørn Olav Åsvold (ORCID: https://orcid.org/0000-0003-3837-2101)
- Lars S. Alfredsson (ORCID: https://orcid.org/0000-0003-1688-6697)
- Jessica Edstorp (ORCID: https://orcid.org/0000-0002-6009-8738)
- Valdemar Grill (ORCID: https://orcid.org/0000-0001-6959-022X)
Institutions
- National Food Administration (SE)
- Norwegian University of Science and Technology (NO)
- Karolinska Institutet (SE)
- Institute for Molecular Medicine Finland (FI)
Publication Details
- Journal
- Clinical Nutrition
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.clnu.2025.09.021
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Stiftelsen för Strategisk Forskning
- Novo Nordisk
- Vetenskapsrådet
- Helse Midt-Norge
- Norges Forskningsråd
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Novo Nordisk Fonden
- National Institutes of Health
- Faculty of Medicine and Health, University of Sydney
- Norwegian Institute of Public Health