PFDN6L Gene Predicts Good Prognosis Associated with Its Inhibition of the Stem-Ness Properties in Hepatocellular Carcinoma
PFDN6L acts as a negative regulator of LCSC-driven tumorigenesis. Its dual blockade of AKT and ERK pathways forms the mechanistic basis of its tumor-suppressive action, supporting its potential as a prognostic biomarker and therapeutic target in HCC.
Authors
- Xiaoyuan Hu (ORCID: https://orcid.org/0009-0007-8233-1143)
- Jiaxing Cheng (ORCID: https://orcid.org/0000-0001-8354-6452)
- Tao Li (ORCID: https://orcid.org/0000-0001-5930-2757)
- Xiaobiao Ma
- Hong Yao (ORCID: https://orcid.org/0000-0002-3333-0925)
- Dan He (ORCID: https://orcid.org/0000-0002-0118-3625)
- Xiaoge Gao (ORCID: https://orcid.org/0000-0003-4858-9398)
- Ling Liu (ORCID: https://orcid.org/0000-0001-8025-1827)
- Li Li (ORCID: https://orcid.org/0000-0002-2505-8212)
- Fangyuan Li (ORCID: https://orcid.org/0000-0002-8086-7362)
- Chunlei Ge (ORCID: https://orcid.org/0009-0004-1342-6403)
Institutions
- Xuzhou Medical College (CN)
- Kunming Medical University (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.32604/or.2025.067628
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00