Successful Management of Accidental Intrathecal Tranexamic Acid Injection: A Case Report from Zambia

Inadvertent intrathecal tranexamic acid injection remains one of the reasons for avoidable morbidity and mortality complications in African countries. A recent review in Anaesthesia highlighted 21 such cases between 1988 and 2018, 10 of which were fatal representing mortality rate above 50%. This is the first successful case report recorded in Zambia, involving a female 17 years old scheduled for an elective exploratory laparotomy due to pelvic mass, who received TXA intrathecally in place of Bupivacaine. The article is emphasizing importance of vigilance in drug administration and early management of such complications.

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Publication Details

Journal
Medical Journal of Zambia
Published
2025-08-16
DOI
https://doi.org/10.55320/mjz.52.4.666
Primary Topic
Genital Health and Disease
Type
article
Field-Weighted Citation Impact
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article

Successful Management of Accidental Intrathecal Tranexamic Acid Injection: A Case Report from Zambia

Mykhailo Danylov, Christine Mwansa Kaluba, Precious Saliya Lupwaya, Lucas Tembo et al.
Medical Journal of Zambia
Genital Health and Disease
article

Successful Management of Accidental Intrathecal Tranexamic Acid Injection: A Case Report from Zambia

Mykhailo Danylov, Christine Mwansa Kaluba, Precious Saliya Lupwaya, Lucas Tembo, Royd Nonde
article en

Abstract

Inadvertent intrathecal tranexamic acid injection remains one of the reasons for avoidable morbidity and mortality complications in African countries. A recent review in Anaesthesia highlighted 21 such cases between 1988 and 2018, 10 of which were fatal representing mortality rate above 50%. This is the first successful case report recorded in Zambia, involving a female 17 years old scheduled for an elective exploratory laparotomy due to pelvic mass, who received TXA intrathecally in place of Bupivacaine. The article is emphasizing importance of vigilance in drug administration and early management of such complications.

Medical Journal of ZambiaVol. 52(4)
European Society of Anaesthesiology (BE), Manor Hospital (GB)
Openalex Percentile: Top 56%
Genital Health and Disease
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Successful Management of Accidental Intrathecal Tranexamic Acid Injection: A Case Report from Zambia — Mykhailo Danylov, Christine Mwansa Kaluba, et al. · Medical Journal of Zambia (2025) | TGRS Research Map | TGRS