Neuroinflammation in Acute Pseudobulbar Palsy: Key Pathways and Biomarkers

Background: Acute pseudobulbar palsy (PBP) secondary to the artery of Percheron (AOP) infarction presents with sudden dysarthria, dysphagia, and emotional lability, but the role of neuroinflammation in its progression remains unclear. Purpose: This study aims to clarify how neuroinflammation affects the course and recovery of acute PBP after AOP infarction by identifying key pathways and potential biomarkers for targeted therapies. Methodology: A literature review from 2018 onwards explored neuroinflammation in stroke and PBP, analyzing data to uncover patterns, gaps, and emerging trends. The Neuroinflammatory Hypothesis of Stroke Recovery guided theoretical analysis. Results/Conclusion: Neuroinflammation contributes to both initial neural damage and subsequent recovery in acute PBP secondary to AOP infarction. Specific inflammatory markers like cytokines and microglial activity may predict outcomes. Targeted therapies modulating neuroinflammation could improve patient outcomes. This research fills critical gaps in understanding PBP's pathophysiology and informs personalized therapeutic approaches.