Indopexines A and B: Two Prenylated Isoindoline Alkaloids from the Fungus <i>Aspergillus</i> sp. TJ507
Indopexines A (<b>1</b>) and B (<b>2</b>), two prenylated isoindoline alkaloids, were isolated from <i>Aspergillus</i> sp. TJ507. Their structures were determined by extensive spectroscopic analysis, CASE algorithms, quantum <sup>1</sup>H and <sup>13</sup>C NMR DP4+, and electronic circular dichroism calculations. Structurally, <b>1</b> was the first examples of isoindoline alkaloids bearing a 6/5/5/6 ring based on the 2-oxa-10-azatetracyclo-[7.7.0.0<sup>1,12</sup>.0<sup>3,8</sup>]cetane core, while <b>2</b> featured an 5,20-bioxa-1-azapencyclo-[10.7.1.0<sup>1,12</sup>.0<sup>6,11</sup>.0<sup>13,18</sup>]lcosane moiety. Furthermore, <b>1</b> displayed an inhibitory effect toward triple-negative breast cancer cells through the Rap1/PI3K/AKT signaling pathway.
Authors
- Jinlong Zhang (ORCID: https://orcid.org/0000-0001-8118-8129)
- Xueqi Lan
- Kuansong Wang
- Changxing Qi (ORCID: https://orcid.org/0000-0001-8596-6303)
- Xinye Huang
- Yeting Zhang (ORCID: https://orcid.org/0000-0002-9611-9051)
- Ming Chen (ORCID: https://orcid.org/0000-0002-3572-6886)
- Qiang Li (ORCID: https://orcid.org/0000-0001-8947-1439)
- Zhengyi Shi (ORCID: https://orcid.org/0009-0009-1954-1142)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Central South University (CN)
- Zhengzhou University (CN)
- Culture Resource (EG)
- Office of Basic Energy Sciences (US)
- Xiangya Hospital Central South University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c03829
- Citations
- 1
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.05