Human-length Telomeres Limit Regeneration of Liver Epithelial Cells in Mice
Short telomeres induce DNA damage in the regenerating liver, hampering its ability to accelerate cell proliferation and regenerate the liver.
Authors
- Yitzhak Reizel (ORCID: https://orcid.org/0000-0002-7736-0018)
- Klaus H. Kaestner (ORCID: https://orcid.org/0000-0002-1228-021X)
- Melissa Rowe
- Yehuda Tzfati (ORCID: https://orcid.org/0000-0001-7720-435X)
- Michael Y. Hu (ORCID: https://orcid.org/0000-0002-3718-7169)
- Mark Tigue
- Riham Smoom (ORCID: https://orcid.org/0000-0002-6769-9798)
Institutions
- Technion – Israel Institute of Technology (IL)
- Hebrew University of Jerusalem (IL)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101655
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00