Successful surgical management of Ménétrier-like disease in a Devon Rex cat

Ménétrier's disease is a rare human condition that causes diffuse hypertrophy of the gastric rugal folds. A similar condition in dogs has been reported as Ménétrier-like disease (MLD). To date, only two feline cases have been reported, and treatment was either unsuccessful or not documented. A 3-year-old female spayed Devon Rex cat was presented with acute nausea, retching, and vomiting. Within two months, multiple tests were performed to reach the diagnosis. Macroscopically, during gastroduodenoscopy, cerebriform hypertrophic gastric mucosal folds were observed in the gastric fundus, cardia, and greater curvature of the stomach. Superficial biopsy sampling of the gastric mucosa showed mild mucosal oedema and low numbers of <i>Helicobacter</i> spp. Considering the course of the disease, persistent gastrointestinal symptoms, and quality of life, a partial gastrectomy was performed. Histology of full-thickness biopsies confirmed hyperplastic fibrosing gastropathy with multifocal cystic dilated gastric glands resembling Ménétrier-like disease in dogs. At the time of the 3-month follow-up, the cat was asymptomatic, and the gastroduodenoscopy was unremarkable. This case report presents clinical findings, challenging diagnostics, and a novel treatment option in a cat with hyperplastic fibrosing gastropathy. To the authors'knowledge, this is the first reported successful surgical management of MLD in a cat.