Comparison of vasopressin to epinephrine during pediatric in-hospital cardiac arrest: survival and physiologic responsiveness
The use of intra-arrest vasopressin is an understudied topic in pediatric cardiac arrest. This study presents a unique comparison of ongoing epinephrine to vasopressin administration, using dose matching to address the limitations of our current vasopressin use. We present a novel analysis of physiologic response to vasopressin using the change in diastolic blood pressure.
Authors
- Sanjiv Mehta (ORCID: https://orcid.org/0000-0002-9983-6742)
- Michael J. Donoghue (ORCID: https://orcid.org/0000-0002-2151-4831)
- Alexis Topjian (ORCID: https://orcid.org/0000-0001-7855-8627)
- Vinay Nadkarni (ORCID: https://orcid.org/0000-0002-3794-5599)
- Lindsay N. Shepard (ORCID: https://orcid.org/0000-0002-6097-8452)
- Garrett Keim (ORCID: https://orcid.org/0000-0002-7054-8798)
- Samridhi Sawhney
- Amanda O’Halloran (ORCID: https://orcid.org/0000-0001-9478-7745)
- Ryan W. Morgan (ORCID: https://orcid.org/0000-0003-1664-5316)
- Todd J. Kilbaugh (ORCID: https://orcid.org/0000-0002-4959-3092)
- Kathryn Graham (ORCID: https://orcid.org/0000-0002-9435-7777)
- Martha Kienzle (ORCID: https://orcid.org/0000-0002-2139-9511)
- Morgann Loaec
- Robert Allen Berg (ORCID: https://orcid.org/0000-0001-5529-9431)
- Kellimarie K. Cooper
- Robert M Sutton
Institutions
- Children's Hospital of Philadelphia (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1038/s41390-025-04374-6
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Hospital of Philadelphia
- National Institutes of Health
- Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine
- National Heart, Lung, and Blood Institute