Estimating treatment effects in trials with outcome data truncated by death: A case study on aligning estimators with estimands
Regarding death as an intercurrent event in the process of defining the estimand for the trial will help clarify the choice of suitable estimators. When choosing the estimators, it is important to consider the assumptions required by the estimators as well as their plausibility given the setting of the trial.
Authors
- Peter Hoskin (ORCID: https://orcid.org/0000-0001-8323-9567)
- Brennan C Kahan (ORCID: https://orcid.org/0000-0001-9957-0844)
- Andre Lopes (ORCID: https://orcid.org/0000-0002-1405-7337)
- Ian R. White (ORCID: https://orcid.org/0000-0002-6718-7661)
- Tra My Pham (ORCID: https://orcid.org/0000-0003-0528-6303)
- Memuna Rashid (ORCID: https://orcid.org/0009-0004-0596-8560)
Institutions
- Cancer Research UK (GB)
- University of Manchester (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Mount Vernon Cancer Centre (GB)
- Cancer Research UK Manchester Institute (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
Publication Details
- Journal
- Clinical Trials
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1177/17407745251360645
- Citations
- 1
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 3.13