Assessment of fluoride ions concentration in novel toothpastes containing fluoridated bioactive glass fillers.

Objective: To measure and compare fluoride release in elutes and suspensions of fluoride doped bioglass (F-BG) enriched novel and commercial dentifrices and to assess effect of filler loading on fluoride release of novel toothpastes. Study Design: In vitro study carried out in triplicates (n=3). Setting: Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan. Period: 3/2020 to 04/2023. Methods: Novel dentifrices were prepared by adding F-BG nanoparticles and zinc oxide as active ingredients to basic dentifrice formulation. Sensodyne F toothpaste was taken as control group. Fluoride release analysis of both suspensions and elutes of dentifrices was carried out via ion selective electrode potentiometry. Collected data was statistically analyzed via SPSS version 22. Results: All novel dentifrices exhibited greater fluoride elusion from Sensodyne F in both elutes and suspensions. In elute and suspension, the observed fluoride release exhibited statistically significant difference within and between all groups where p > 0.05 was taken as significant. Conclusion: In toothpastes, type of fluoride source directs fluoride release behavior. Direct proportionality of fluoride release of novel dentifrices to filler loading was observed.