Risk stratification of high-risk muscle invasive upper urinary tract urothelial carcinoma: multi-institutional study
Patients with high-risk pT2 UTUC had significantly worse survival outcomes compared to those with low-risk pT2 UTUC. These findings suggest that further refinement of clinical trial designs is needed to better identify high-risk pT2 UTUC patients who may benefit from more aggressive treatment strategies, such as adjuvant therapy, while minimizing unnecessary systemic therapy in low-risk pT2 UTUC patients. Future studies should validate these findings and help establish the true value of systemic therapy for this patient population.
Authors
- Chi‐Ping Huang (ORCID: https://orcid.org/0000-0003-1429-1366)
- Hao‐Lun Luo (ORCID: https://orcid.org/0000-0002-5988-0474)
- Shih-Hsiu Lo
- Hung‐Lung Ke (ORCID: https://orcid.org/0000-0002-4208-3858)
- Wei‐Ming Li (ORCID: https://orcid.org/0000-0001-6155-0696)
- Hung‐Jen Wang (ORCID: https://orcid.org/0000-0003-0910-5581)
- Shu‐Yu Wu (ORCID: https://orcid.org/0000-0002-3586-5974)
- Yi‐Huei Chang
- Yao-Chou Tsai
Institutions
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Taipei Medical University Hospital (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- China Medical University Hospital (TW)
- Pingtung Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1007/s00345-025-05915-8
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung University
- Chang Gung Medical Foundation
- Kaohsiung Chang Gung Memorial Hospital