Dual Malignancies in <scp>IgG4</scp> ‐Related Disease: A Diagnostic and Therapeutic Challenge
We report a rare case of IgG4-related disease (IgG4-RD) presenting with retroperitoneal fibrosis and autoimmune pancreatitis, followed by sequential development of papillary thyroid carcinoma and diffuse large B cell lymphoma. Histopathologic and positron emission tomography-computed tomography findings were essential for diagnosis and guided timely treatment. This case highlights the potential oncogenic link between chronic IgG4-driven inflammation and B cell malignancy, emphasizing the need for vigilant cancer surveillance in patients with IgG4-RD.
Authors
- Lina Zhang (ORCID: https://orcid.org/0000-0002-2018-1756)
- Ming Zhang (ORCID: https://orcid.org/0000-0001-7111-4345)
- Ji Li (ORCID: https://orcid.org/0000-0003-2201-5679)
- Sheng‐Guang Li (ORCID: https://orcid.org/0000-0002-8047-9984)
- Juanjuan Song (ORCID: https://orcid.org/0000-0002-6550-6294)
Institutions
- Peking University (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/acr2.70114
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00