Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care
The CloSed data suggest that higher doses of clonidine and midazolam than are commonly used in clinical practice should be considered to provide adequate sedation in critically ill children.
Authors
- Frank Dörje (ORCID: https://orcid.org/0000-0003-0227-9212)
- Mari‐Liis Ilmoja (ORCID: https://orcid.org/0000-0001-7769-1864)
- Pavla Pokorná (ORCID: https://orcid.org/0000-0001-6803-7350)
- Manuel A. Baarslag (ORCID: https://orcid.org/0000-0003-4376-234X)
- Catherine Tuleu (ORCID: https://orcid.org/0000-0001-8384-357X)
- Alessandra Simonetti (ORCID: https://orcid.org/0000-0002-0890-0519)
- Dick Tibboel (ORCID: https://orcid.org/0000-0003-4331-5398)
- Antje C. Neubert (ORCID: https://orcid.org/0000-0001-6575-1452)
- Stefan Jakob Wimmer (ORCID: https://orcid.org/0000-0002-7195-7155)
- Michael Andreas Schroth
- Joost van Rosmalen (ORCID: https://orcid.org/0000-0002-9187-244X)
- Maddlie Bardol
- Yucheng Sheng (ORCID: https://orcid.org/0000-0003-1460-5070)
- Brian J. Anderson (ORCID: https://orcid.org/0000-0002-2826-3019)
- Per‐Arne Lönnqvist (ORCID: https://orcid.org/0000-0002-8586-1429)
- Joseph Frank Standing (ORCID: https://orcid.org/0000-0002-4561-7173)
- Wolfgang Rascher (ORCID: https://orcid.org/0000-0003-0395-8487)
- Adriana Ceci (ORCID: https://orcid.org/0000-0002-8778-3612)
- Irmgard Toni (ORCID: https://orcid.org/0000-0002-0089-1494)
- Peter Larsson (ORCID: https://orcid.org/0000-0003-3143-6643)
- Thomas M.K. Völkl
- Tuuli Methsvat
Institutions
- University of Rome Tor Vergata (IT)
- University of London (GB)
- Karolinska University Hospital (SE)
- University of Auckland (NZ)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Charles University (CZ)
- Erasmus MC (NL)
- University Hospital Augsburg (DE)
- Universitätsklinikum Erlangen (DE)
- Tallinn Health Care College (EE)
- Cnopf´sche Kinderklinik (DE)
- Bambino Gesù Children's Hospital (IT)
- Fondazione per la Ricerca Farmacologica Gianni Benzi Onlus (IT)
- General University Hospital in Prague (CZ)
- University College London (GB)
- University of Tartu (EE)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Pediatric Anesthesia
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1111/pan.70050
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission