Impact of <i>CYP1A</i> , <i>CYP2C19</i> , <i>CYP2D6</i> , <i>CYP3A4</i> , <i>CYP3A5</i> , and <i>NFIB</i> genotypes on clozapine serum concentration in smokers and nonsmokers

The <i>CYP1A T</i>, <i>NFIB C</i>, and <i>CYP3A5*1</i> alleles have significant impact on clozapine serum levels. Incorporating genotype information for these variants, together with patient smoking status, would improve algorithms for precision dosing of clozapine.

Authors

Olav B. Smeland (ORCID: https://orcid.org/0000-0002-3761-5215)
Espen Molden (ORCID: https://orcid.org/0000-0001-6190-2751)
Line Skute Bråten (ORCID: https://orcid.org/0000-0001-6887-1986)
Hasan Çağın Lenk (ORCID: https://orcid.org/0000-0003-4724-7396)

Institutions

Oslo University Hospital (NO)
University of Oslo (NO)
Diakonhjemmet Hospital (NO)

Publication Details

Journal: Therapeutic Advances in Psychopharmacology
Published: 2025-10-01
DOI: https://doi.org/10.1177/20451253251377183
Citations: 1
Primary Topic: Pharmacogenetics and Drug Metabolism
Type: article
Field-Weighted Citation Impact: 1.56

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article

Impact of CYP1A , CYP2C19 , CYP2D6 , CYP3A4 , CYP3A5 , and NFIB genotypes on clozapine serum concentration in smokers and nonsmokers

Olav B. Smeland, Espen Molden, Line Skute Bråten, Hasan Çağın Lenk

Oct 1, 2025

1 citations

Therapeutic Advances in Psychopharmacology

Pharmacogenetics and Drug Metabolism

1.56

article

Impact of CYP1A , CYP2C19 , CYP2D6 , CYP3A4 , CYP3A5 , and NFIB genotypes on clozapine serum concentration in smokers and nonsmokers

Olav B. Smeland, Espen Molden, Line Skute Bråten, Hasan Çağın Lenk

October 1, 2025article en

1 citations

Abstract

The <i>CYP1A T</i>, <i>NFIB C</i>, and <i>CYP3A5*1</i> alleles have significant impact on clozapine serum levels. Incorporating genotype information for these variants, together with patient smoking status, would improve algorithms for precision dosing of clozapine.

Therapeutic Advances in PsychopharmacologyVol. 15

Oslo University Hospital (NO), University of Oslo (NO), Diakonhjemmet Hospital (NO)

Openalex Percentile: Top 15%

Pharmacogenetics and Drug Metabolism

1.56

DOI Open Access PDF OpenAlex

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Impact of <i>CYP1A</i> , <i>CYP2C19</i> , <i>CYP2D6</i> , <i>CYP3A4</i> , <i>CYP3A5</i> , and <i>NFIB</i> genotypes on clozapine serum concentration in smokers and nonsmokers — Olav B. Smeland, Espen Molden, et al. · Therapeutic Advances in Psychopharmacology (2025) | TGRS Research Map | TGRS