Trends and efficacy of definitive radiotherapy regimens for locally advanced head and neck cancer in elderly patients: A population-based analysis by the German cancer registry group
Platinum-based RCTx remains the most effective treatment for elderly HNSCC patients. RT-Cet is associated with poorer outcome particularly in patients > 70 years, underscoring the need for age-adapted, biology-informed treatment strategies.
Authors
- Daniel Zips (ORCID: https://orcid.org/0000-0001-5779-9675)
- Ian Wittenberg
- Andrea Sackmann
- Christian Doll (ORCID: https://orcid.org/0000-0002-0439-759X)
- Steffen Dommerich (ORCID: https://orcid.org/0000-0001-7769-0634)
- Anne Letsch
- Anna Trelinska-Finger
- Fabian Reinwald
- Barbara Franke (ORCID: https://orcid.org/0000-0003-4375-6572)
- Marcus Beck (ORCID: https://orcid.org/0000-0003-1940-2571)
- Ingeborg Tinhofer (ORCID: https://orcid.org/0000-0002-0512-549X)
- Sylke Ruth Zeißig (ORCID: https://orcid.org/0000-0002-0743-6128)
- Ulrich Keilholz (ORCID: https://orcid.org/0000-0001-6773-9406)
- Elena Hofmann (ORCID: https://orcid.org/0000-0003-4458-9278)
- Maren Knödler (ORCID: https://orcid.org/0000-0001-7475-6829)
- Konrad Klinghammer (ORCID: https://orcid.org/0000-0001-6425-4833)
- Monika Klinkhammer‐Schalke (ORCID: https://orcid.org/0000-0001-5066-2051)
- Max Heiland (ORCID: https://orcid.org/0000-0002-4987-2913)
- Kerstin Weitmann (ORCID: https://orcid.org/0000-0003-0386-283X)
- Constanze Schneider
- T. Saraei
Institutions
- Hess (United States) (US)
- University of Würzburg (DE)
- Universitätsmedizin Greifswald (DE)
- Humboldt-Universität zu Berlin (DE)
- German Cancer Society (DE)
- Experimental Factory Magdeburg (DE)
- NHS Digital (GB)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Brandenburg University of Technology Cottbus-Senftenberg (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.ejca.2025.116039
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00