Isotype-selective roles of hepatic acetyl-CoA carboxylases in a mouse model of fatty liver disease
Our results indicate that complete inhibition of liver ACC activity is required to resolve fatty liver disease and fibrosis, with ACC1 inhibition being the dominant driver of unwanted metabolic dysregulation. Accordingly, selective inhibition of ACC2 with partial inhibition of ACC1 may represent a refined future approach to reverse fatty liver disease phenotypes while minimizing metabolic dysregulation.
Authors
- Brenna Osborne (ORCID: https://orcid.org/0000-0002-0197-3010)
- Kyle L. Hoehn (ORCID: https://orcid.org/0000-0002-0214-3238)
- Frances L. Byrne (ORCID: https://orcid.org/0000-0002-8897-8438)
- Mingyan Zhou (ORCID: https://orcid.org/0000-0002-9210-4151)
- Riya Shrestha (ORCID: https://orcid.org/0000-0001-8322-4189)
- Ellen M. Olzomer (ORCID: https://orcid.org/0000-0002-5823-0736)
- S Y Zhang
- Martina Beretta (ORCID: https://orcid.org/0000-0001-6415-1287)
- Adam Hargreaves (ORCID: https://orcid.org/0000-0003-0772-7627)
- Calum S Vancuylenburg
Institutions
- UNSW Sydney (AU)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.molmet.2025.102264
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00