Wnt/β-catenin signaling regulates cardiac Cx43 in a metabolic substrate-dependent manner
These data demonstrate that metabolic substrates regulate the effects of Wnt/β-catenin signaling in cardiomyocytes, with reductions in Cx43 mRNA and protein only observed when glucose is the primary metabolic substrate, which occurs in arrhythmogenic conditions such as cardiac hypertrophy and heart failure.
Authors
- Jerry Wang (ORCID: https://orcid.org/0000-0002-9746-1211)
- Ying Xia (ORCID: https://orcid.org/0000-0002-0126-6594)
- Ruonan Gu (ORCID: https://orcid.org/0000-0002-5007-3836)
- Darryl R. Davis (ORCID: https://orcid.org/0000-0001-9642-3910)
- Aizhu Lu (ORCID: https://orcid.org/0000-0002-4116-148X)
- Peter P. Liu (ORCID: https://orcid.org/0000-0002-3017-1199)
- Hongwei Wang (ORCID: https://orcid.org/0000-0003-2868-5112)
- Wenbin Liang (ORCID: https://orcid.org/0000-0001-8131-0112)
- Omar Kayyem
Institutions
- University of Ottawa (CA)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100488
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00