Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma
Colorectal SRCC is a clinically and molecularly distinct and highly malignant subtype compared to AC. It exhibits a "pseudo-T cell-inflamed" tumor microenvironment with increased total CD8<sup>+</sup> TILs but reduced PD-1<sup>+</sup>CD8<sup>+</sup> TIL infiltration. Notably, PD-1<sup>+</sup>CD8<sup>+</sup> TIL infiltration is associated with favorable prognosis. These findings provide new insights into tumor-immune interactions in SRCC, with potential implications for prognostic stratification and the development of personalized immunotherapeutic strategies.
Authors
- Lan Su (ORCID: https://orcid.org/0000-0002-8692-3310)
- Xinxin Mao (ORCID: https://orcid.org/0000-0002-2938-1025)
- Chentong Wang (ORCID: https://orcid.org/0009-0006-1590-6675)
- Huanwen Wu (ORCID: https://orcid.org/0000-0002-3996-3176)
- Guole Lin (ORCID: https://orcid.org/0000-0001-6225-3028)
- Yuhua Gong (ORCID: https://orcid.org/0000-0001-7893-2084)
- Lin Cong (ORCID: https://orcid.org/0000-0002-1334-9047)
- Bo Chen (ORCID: https://orcid.org/0000-0003-0812-5775)
- Yang An (ORCID: https://orcid.org/0000-0002-9335-6975)
- Han Chen
- Jiaolin Zhou (ORCID: https://orcid.org/0000-0003-2020-5161)
- Yaping Xu (ORCID: https://orcid.org/0000-0002-6741-3913)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Burning Rock Biotech (China) (CN)
- Dian Diagnostics (China) (CN)
Publication Details
- Journal
- Journal of the National Cancer Center
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jncc.2025.06.006
- Primary Topic
- Colorectal and Anal Carcinomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00