Formation of CO2-dependent small-colony variants (SCVs) in methicillin-resistant Staphylococcus aureus mediated by a single point mutation in mpsB
Our findings demonstrate that a single mpsB mutation drives SCV emergence, highlighting its role in persistent infections and providing potential targets for therapeutic intervention.
Authors
- Wanyang Dong
- Junyan Liu (ORCID: https://orcid.org/0000-0001-6549-4388)
- Yanrui Ye (ORCID: https://orcid.org/0000-0002-8501-1408)
- Yi Cai (ORCID: https://orcid.org/0000-0003-2296-222X)
- Zhenbo Xu
- Sisi Chen (ORCID: https://orcid.org/0000-0001-9448-9713)
- Song Li (ORCID: https://orcid.org/0000-0002-1664-6290)
- Tian Zhong
- Xiping Qian
- Wenchang Yuan (ORCID: https://orcid.org/0000-0003-2911-1102)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shantou University (CN)
- Kingmed Diagnostics (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
- Zhongkai University of Agriculture and Engineering (CN)
Publication Details
- Journal
- Biofilm
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.bioflm.2025.100320
- Citations
- 2
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 2.79