Inhibition, But Not Depletion, of Erk Signaling Ameliorates Anthracycline-Induced Cardiotoxicity in Zebrafish
Aberrant Erk activation contributes to AIC, and controlled Erk inhibition may offer therapeutic benefit, potentially via antiaging mechanisms. However, optimization is essential, as excessive inhibition can be cardiotoxic.
Authors
- Xiaolei Xu (ORCID: https://orcid.org/0000-0002-4928-3422)
- Feixiang Yan
- Maryam Moossavi (ORCID: https://orcid.org/0000-0002-6891-535X)
- David Mondaca‐Ruff (ORCID: https://orcid.org/0000-0001-9211-2963)
- Yonghe Ding (ORCID: https://orcid.org/0000-0002-4531-1721)
- Ping Zhu (ORCID: https://orcid.org/0000-0003-4309-1814)
- Xueling Ma
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jaccao.2025.08.005
- Citations
- 1
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.15