Reduced Intestinal GLP-1+ Cell Numbers Are Associated With an Inflammation-related Epithelial Metabolic Signature
Reduction of GLP-1<sup>+</sup> cells represents a general feature of ileal and colonic inflammation in mice and humans. Given the numerous properties of GLP-1, this reduction likely affects inflammatory processes in the mucosa and disease-related symptoms on multiple levels, and therefore, should be considered a therapeutic target in inflammatory bowel diseases.
Authors
- Eva Rath (ORCID: https://orcid.org/0000-0003-1910-1162)
- Dirk Haller (ORCID: https://orcid.org/0000-0002-6977-4085)
- Julien Planchais (ORCID: https://orcid.org/0000-0002-3427-7425)
- Nadine Waldschmitt
- Doriane Aguanno (ORCID: https://orcid.org/0000-0002-4154-3592)
- Mohamed Ahmed (ORCID: https://orcid.org/0000-0001-8048-8605)
- R. Balfour Sartor (ORCID: https://orcid.org/0000-0002-7820-632X)
- Sevana Khaloian (ORCID: https://orcid.org/0009-0009-9154-8103)
- Tobias Fromme (ORCID: https://orcid.org/0000-0001-9150-2513)
- Katharina Kuellmer (ORCID: https://orcid.org/0009-0001-1753-0978)
- Amira Metwaly (ORCID: https://orcid.org/0000-0001-5740-0230)
- Harry Sokol (ORCID: https://orcid.org/0000-0002-2914-1822)
- Elisabeth Urbauer (ORCID: https://orcid.org/0009-0003-5704-3589)
- Gabriele Hörmannsperger
Institutions
- University of North Carolina at Chapel Hill (US)
- Inserm (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Recherche Saint-Antoine (FR)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101656
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00