Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation
Our studies indicate that PRM1 and PRM2 may bind to and condense distinct genomic regions in somatic cells, resulting in widespread silencing of gene expression, while retaining a largely stable DNA methylome.
Authors
- Gina Esther Merges (ORCID: https://orcid.org/0000-0002-5805-965X)
- Hubert Schorle (ORCID: https://orcid.org/0000-0001-8272-0076)
- Wolfgang Wagner (ORCID: https://orcid.org/0000-0002-1971-3217)
- Deepika Puri (ORCID: https://orcid.org/0000-0002-7687-7226)
- Monica Varona Baranda
- Esra Dursun Torlak
- Alexandra Bott
Institutions
- University Hospital Bonn (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1186/s13072-025-00633-2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00