Failure-to-rescue as a determinant of overall survival following resection for perihilar cholangiocarcinoma
While OS in pCCA has improved over recent decades, it remains a malignancy of high surgical complexity and perioperative risk. Our study identified the reduction in FTR as the key determinant of improved outcomes, driven by increased use of rescue strategies and a shift from surgical to non-operative interventions. Although adjuvant therapy became more common over time and contributed to survival gains, its benefit diminished after adjusting for early postoperative mortality. Meanwhile, the declining rate of dropouts further reflects advances in diagnostics and patient selection, emphasizing the importance of multidisciplinary, centralized care in pCCA management.
Authors
- Gregory James Gores (ORCID: https://orcid.org/0000-0003-3151-009X)
- Patrick P. Starlinger (ORCID: https://orcid.org/0000-0002-4666-5337)
- Sumera I. Ilyas (ORCID: https://orcid.org/0000-0002-2709-3003)
- John E. Eaton (ORCID: https://orcid.org/0000-0002-8029-4947)
- Zhihao Li (ORCID: https://orcid.org/0000-0002-5654-7043)
- Susanne G. Warner (ORCID: https://orcid.org/0000-0003-4329-7943)
- David M. Nagorney (ORCID: https://orcid.org/0000-0003-4053-9476)
- Rory L. Smoot (ORCID: https://orcid.org/0000-0001-8543-661X)
- Yawen Dong (ORCID: https://orcid.org/0000-0002-3631-1228)
- V. Podrascanin (ORCID: https://orcid.org/0009-0004-9684-8918)
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101615
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00