Increased production of humoral factor and PD-L1 expression induced by cytokine stimulation play a key role in the immunosuppressive effects of stem cells derived from human exfoliated deciduous teeth
We demonstrated that the use of SHED in its activated state effectively suppresses immune response and maintains graft function at the time of islet transplantation.
Authors
- Kenta Iwasaki (ORCID: https://orcid.org/0000-0003-3229-5192)
- Shin Tsunekawa (ORCID: https://orcid.org/0000-0002-9890-5777)
- Takako Izumoto
- Akihito Yamamoto (ORCID: https://orcid.org/0000-0002-9206-1243)
- Tatsuhito Himeno
- K. Ishiyama
- Takaaki Kobayashi (ORCID: https://orcid.org/0000-0001-8335-0361)
- Makoto Kato (ORCID: https://orcid.org/0000-0001-7166-6385)
- Yusuke Hayashi (ORCID: https://orcid.org/0000-0003-2365-1220)
- Masaki Kondo (ORCID: https://orcid.org/0000-0003-0558-3404)
- Hideki Kamiya (ORCID: https://orcid.org/0000-0003-3197-2542)
- Yuko Miwa
Institutions
- Aichi Medical University (JP)
- Tokushima Municipal Hospital (JP)
- Gifu University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102295
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00