Loss of fibronectin fiber tension is inherent to ECM remodeling in human myocarditis and post-inflammatory fibrosis
Our data suggest that relaxed fibronectin fibers are a recurrent feature of myocarditis and associate with measures of cardiac dysfunction. These findings suggest that fibronectin fiber tension might be a mechanobiological signature that warrants validation in larger, longitudinal cohorts and evaluation of in-vivo measurability.
Authors
- Krishna Chander Sridhar (ORCID: https://orcid.org/0000-0001-8108-7627)
- Sophie Van Linthout (ORCID: https://orcid.org/0000-0002-7581-7870)
- Julia Mehl (ORCID: https://orcid.org/0000-0002-8279-7142)
- Viola Vogel (ORCID: https://orcid.org/0000-0003-2898-7671)
- Karin Klingel (ORCID: https://orcid.org/0000-0003-0203-2498)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Carsten Tschöpe (ORCID: https://orcid.org/0000-0001-5243-8985)
- Mario Thiele
Institutions
- ETH Zurich (CH)
- Universitätsklinikum Tübingen (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Matrix Biology Plus
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.mbplus.2025.100182
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39