Pediatric-inspired (R3) vs. Adult salvage (FA) chemotherapy in relapsed adolescents and young adults (AYA) acute lymphoblastic leukemia (ALL): A comparative outcome analysis
The pediatric-inspired R3 and adult-based FA regimens yielded similar survival and remission rates in relapsed AYA-ALL. Distinct toxicity profiles suggest that treatment selection should be individualized. Larger, prospective studies are warranted to validate the role of pediatric salvage protocols in this challenging population.
Authors
- Amr Hanbali (ORCID: https://orcid.org/0000-0003-0208-0713)
- Riad El Fakih (ORCID: https://orcid.org/0000-0003-4498-3865)
- Mohammed Alshehri (ORCID: https://orcid.org/0000-0003-1278-8475)
- Chokri Ben Lamine
- Tusneem Elhassan (ORCID: https://orcid.org/0000-0002-1625-1168)
- Feras Alfraih
- Lara Samhan (ORCID: https://orcid.org/0000-0002-6595-859X)
- Maha Abdullah Hassan
- Syed Osman Ahmed
Institutions
- Alfaisal University (SA)
- King Faisal Specialist Hospital & Research Centre (SA)
- Saudi Center for Organ Transplantation (SA)
Publication Details
- Journal
- Leukemia Research Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.lrr.2025.100548
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00