Photoredox‐Catalyzed Direct Decarboxylative Amination of Alkyl Carboxylic Acids Enabled by a Novel <i>N</i> ‐Centered Radical Scavenger

Comprehensive Summary Alkylamines play an important role in medicinal chemistry, while carboxylic acids are commonly found in many natural products and pharmaceuticals. In this study, we developed a direct photoredox‐catalyzed decarboxylative amination of alkyl carboxylic acids using a novel N ‐centered radical scavenger. This method avoids pre‐activation and transition‐metal catalysts, allowing a diverse range of readily available carboxylic acids to be efficiently converted into medicinally valuable amines. Further mechanistic studies and DFT calculations were conducted to provide evidence for the proposed photoredox‐catalyzed pathway. This protocol is operationally simple and has excellent functional group compatibility, which is likely to be of great use in synthetic chemistry