Iron Deficiency Definitions in Heart Failure Across Ejection Fraction Phenotypes
Irrespective of definition, ID was highly prevalent (highest in HFpEF) and independently associated with worse symptoms or HR-QoL. ID defined as TSAT <20% showed the strongest associations with outcomes, including mortality and HF or cardiovascular/noncardiovascular hospitalizations, likely representing the preferred definition with which to enroll a higher-risk group in trials.
Authors
- Ulrika Löfström (ORCID: https://orcid.org/0009-0009-3972-0172)
- Gianluigi Savarese (ORCID: https://orcid.org/0000-0001-7732-0887)
- Giulia Ferrannini (ORCID: https://orcid.org/0000-0002-0318-7435)
- John G.F. Cleland (ORCID: https://orcid.org/0000-0002-1471-7016)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Lina Benson (ORCID: https://orcid.org/0000-0002-5393-0055)
- Carin Corovic Cabrera
- Stephan von Haehling (ORCID: https://orcid.org/0000-0002-9818-042X)
- Charlotta Ljungman (ORCID: https://orcid.org/0000-0002-2785-1919)
- Stefan D. Anker
- Lars H. Lund (ORCID: https://orcid.org/0000-0003-1411-4482)
- Felix Lindberg (ORCID: https://orcid.org/0000-0002-7380-9877)
- Krister Lindmark (ORCID: https://orcid.org/0000-0002-5756-7791)
- Camilla Hage (ORCID: https://orcid.org/0000-0002-4142-2416)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- British Heart Foundation (GB)
- Stockholm South General Hospital (SE)
- Baylor Medical Center at Garland (US)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- Research Institute of Dallas (US)
- University of Göttingen (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-10-04
- DOI
- https://doi.org/10.1016/j.jchf.2025.102662
- Citations
- 2
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.54